Spiro I J, Sapareto S A, Raaphorst G P, Dewey W C
Int J Radiat Oncol Biol Phys. 1982 Jan;8(1):53-8. doi: 10.1016/0360-3016(82)90384-4.
Survival studies with Chinese hamster ovary cells showed that thermal tolerance, which developed during chronic heating (treatment times greater than or equal to 1 hr) or after acute heating (treatment times less than 1 hr) involves similar mechanisms. For example, cells that expressed thermal tolerance during a 6-14 hr chronic heat treatment at 41.5 degrees C or 42 degrees C also expressed thermal tolerance to a subsequent acute treatment at 45.5 degrees C. Also, cells heated acutely for 10 min at 45.5 degrees C and incubated at 37 degrees C for 12 hr showed tolerance to both 45.5 degrees C acute and 42 degrees C chronic hyperthermia. Finally, thermal tolerance developed between fractionated acute heat treatment at 45.5 degrees C and fractionated chronic heat treatments at 42.5 degrees C. These data indicate that when cells are tolerant to chronic hyperthermia they are also tolerant to acute hyperthermia and that the reverse is also true.
对中国仓鼠卵巢细胞的存活研究表明，在慢性加热（处理时间大于或等于1小时）期间或急性加热（处理时间小于1小时）后产生的热耐受性涉及相似的机制。例如，在41.5摄氏度或42摄氏度下进行6至14小时慢性热处理期间表现出热耐受性的细胞，对随后在45.5摄氏度下的急性处理也表现出热耐受性。此外，在45.5摄氏度下急性加热10分钟并在37摄氏度下孵育12小时的细胞，对45.5摄氏度急性热疗和42摄氏度慢性热疗均表现出耐受性。最后，在45.5摄氏度的分次急性热处理和42.5摄氏度的分次慢性热处理之间产生了热耐受性。这些数据表明，当细胞对慢性热疗耐受时，它们对急性热疗也耐受，反之亦然。
