Innes D L, Tansy M F
Neurotoxicology. 1981 Nov;2(3):515-22.
Inhalation experiments were conducted by exposing mature male Sprague-Dawley rats to methyl methacrylate (MMA) monomer vapor in air. The effects upon central neuronal activity associated with acute exposures of chloralose-urethanized rats to monomeric MMA vapor concentrations are summarized in this report. The most remarkable and readily apparent phenomenon was the depression of multiple-unit electrical activity in the lateral hypothalamus and ventral hippocampus of rats which were exposed to 400 ppm of MMA in air for 60 min. In marked contrast, recordings made from the parietal cortex, cerebellum, dorsal hippocampus, medial amygdala, ventral medial hypothalamus, anterior hypothalamus, septum, and mammillary body following comparable exposures showed insignificant changes in multiple-unit electrical activity.
通过将成年雄性斯普拉格-道利大鼠暴露于空气中的甲基丙烯酸甲酯（MMA）单体蒸气进行吸入实验。本报告总结了水合氯醛-乌拉坦麻醉的大鼠急性暴露于单体MMA蒸气浓度时对中枢神经元活动的影响。最显著且显而易见的现象是，暴露于空气中400 ppm的MMA 60分钟的大鼠，其外侧下丘脑和腹侧海马体中的多单位电活动受到抑制。相比之下，在类似暴露后，从顶叶皮质、小脑、背侧海马体、内侧杏仁核、腹内侧下丘脑、前下丘脑、隔区和乳头体记录到的多单位电活动变化不显著。
