Günther T, Ising H, Mohr-Nawroth F, Chahoud I, Merker H J
Teratology. 1981 Oct;24(2):225-33. doi: 10.1002/tera.1420240213.
Pregnant rats an mice received a magnesium (Mg)-deficient diet with different Mg contents from 40 t 360 ppm. The control received 2,000 ppm. At the end of gestation, the Mg concentration in the maternal serum was found to have decreased by up to 0.3 mmole/liter, depending on the Mg content of the food. Mg-dose-dependent embryotoxic effects (resorptions, retardation, disturbed bone development, and skeletal malformations) were observed only below a threshold value of 0.7 mmole/liter of the maternal serum Mg concentration. Noise stress in rats, in addition to a mild Mg deficiency (360 ppm Mg), which by itself had no effects, increased the rate of resorptions only.
怀孕的大鼠和小鼠食用了镁（Mg）含量从40 ppm到360 ppm不等的缺镁饮食。对照组的镁含量为2000 ppm。在妊娠末期，发现母体血清中的镁浓度根据食物中的镁含量最多降低了0.3毫摩尔/升。仅在母体血清镁浓度低于0.7毫摩尔/升的阈值时，才观察到镁剂量依赖性胚胎毒性作用（吸收、发育迟缓、骨骼发育紊乱和骨骼畸形）。除了轻度缺镁（360 ppm镁）本身没有影响外，大鼠的噪声应激仅增加了吸收发生率。
