[Effect of castration and mouse strain on 1, 2-dimethylhydrazine induction of pararenal angiosarcomas and kidney adenomas].

Castration preceding the administration of 1, 2-dimethylhydrazine (DMH) to CBA male mice inhibits the induction of pararenal angiosarcomas (from 76% to naught) and renal adenomas (from 89 to 57%). Male mice of different strains treated with DMH developed the following incidences of pararenal angiosarcomas and renal adenomas: C3H - 35.5 and 13%, respectively, CBA - 97 and 78.8%,m (CBA X C57B1) F1-36.1 and 30%. C57B1-4.2 and 23.4%, BALB/c-13 and 43.4%, C3HA -7.1 and 14.3%. Pararenal angiosarcoma develops most likely from vascular bed of renal capsula. The mechanisms of androgen stimulation of renal adenoma and pararenal angiosarcoma induction are discussed.