Ravindran R S, Turner M S, Muller J
Anesth Analg. 1982 Mar;61(3):279-83.
The purpose of this study was to evaluate the neurologic consequences of deliberate subarachnoid injection of large volumes of 2-chloroprocaine-CE in experimental animals. The possible role of low pH as well as total volume as potential factors in causing neurotoxicity was evaluated. The 65 dogs in the study received injections in the subarachnoid space as follows: 6 to 8 ml of bupivacaine (N = 15), 2-chloroprocaine-CE (N = 20), low pH normal saline (pH 3.0) (N = 20), or normal saline (N = 10). Of the 20 animals that received subarachnoid injection of 2-chloroprocaine-CE seven (35%) developed hind-limb paralysis. None of the animals that received bupivacaine, normal saline, or normal saline titrated to a pH 3.0 developed hind-limb paralysis. Of the 15 spinal cords of the animals that received 2-chloroprocaine-CE, 13 showed subpial necrosis; the nerve roots and subarachnoid vessels were normal. The spinal cords of the animals that received bupivacaine, low pH normal saline (pH 3.0), or normal saline did not show abnormal findings.
本研究的目的是评估在实验动物中故意蛛网膜下腔注射大量2-氯普鲁卡因-CE的神经学后果。评估了低pH值以及总体积作为导致神经毒性的潜在因素的可能作用。研究中的65只狗接受了如下蛛网膜下腔注射：6至8毫升布比卡因（N = 15）、2-氯普鲁卡因-CE（N = 20）、低pH值生理盐水（pH 3.0）（N = 20）或生理盐水（N = 10）。在接受蛛网膜下腔注射2-氯普鲁卡因-CE的20只动物中，7只（35%）出现后肢麻痹。接受布比卡因、生理盐水或pH值调至3.0的生理盐水注射的动物均未出现后肢麻痹。在接受2-氯普鲁卡因-CE注射的动物的15个脊髓中，13个显示软膜下坏死；神经根和蛛网膜下腔血管正常。接受布比卡因、低pH值生理盐水（pH 3.0）或生理盐水注射的动物的脊髓未显示异常发现。
