利福霉素S向利福霉素B和L的转化。对当前生物合成假说的修正。
Transformation of rifamycin S into rifamycins B and L. A revision of the current biosynthetic hypothesis.
作者信息
Ghisalba O, Roos R, Schupp T, Nüesch J
出版信息
J Antibiot (Tokyo). 1982 Jan;35(1):74-80. doi: 10.7164/antibiotics.35.74.
PMID:7200089
Abstract
The transformation of rifamycin S into rifamycins B and L was reinvestigated in order to establish more detailed pathways. Our results exclude rifamycin O as a common progenitor in the biosyntheses of rifamycins B and L. Rifamycins B and L are formed from rifamycin S (SV) by different pathways using different C3-precursors for the biosynthesis of their glycolic acid moieties. A thiamine-dependent enzyme (decarboxylase) seems to be involved in the transformation reaction.
摘要
为了建立更详细的途径，对利福霉素S转化为利福霉素B和L的过程进行了重新研究。我们的结果排除了利福霉素O作为利福霉素B和L生物合成中的共同前体。利福霉素B和L由利福霉素S（SV）通过不同途径形成，在其乙醇酸部分的生物合成中使用不同的C3前体。一种硫胺素依赖性酶（脱羧酶）似乎参与了转化反应。
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