Feldman J G, Stein S C, Klein R J, Kohl S, Casey G
J Chronic Dis. 1982;35(1):53-60. doi: 10.1016/0021-9681(82)90029-7.
Records of almost 174,000 consecutive births at six Brooklyn hospitals during the years 1968-1976 were reviewed for congenital neural tube defects. Prevalence of anencephaly, myelomeningocele and occipital encephalocele combined was significantly higher in infants delivered to mothers born in Puerto Rico than in offspring of non-Puerto Rican whites or blacks. The association of prevalence rates with ethnicity remained significant after adjustment for several variables. However, when adjustment was made for private or service status the difference between Puerto Ricans and whites, although still appreciable, was no longer statistically significant. No significant differences in prevalence rates between whites and blacks were observed. Sex ratios of affected infants were close to unity in each ethnic group. Statistically significant associations were found between the prevalence of neural tube defects and parity, gravidity and economic status. The patterns of these associations varied among the ethnic groups. A declining trend in the prevalence of myelomeningocele was observed for all ethnic groups.
对1968年至1976年期间布鲁克林六家医院近17.4万例连续分娩记录进行了先天性神经管缺陷审查。波多黎各出生的母亲所生婴儿中无脑儿、脊髓脊膜膨出和枕部脑膨出合并症的患病率显著高于非波多黎各白人或黑人的后代。在对几个变量进行调整后，患病率与种族的关联仍然显著。然而，在对私人或服务状况进行调整后，波多黎各人和白人之间的差异虽然仍然明显，但不再具有统计学意义。未观察到白人和黑人在患病率上有显著差异。每个种族组中受影响婴儿的性别比接近1。神经管缺陷的患病率与产次、妊娠次数和经济状况之间存在统计学上的显著关联。这些关联模式在不同种族组中有所不同。所有种族组的脊髓脊膜膨出患病率均呈下降趋势。
