Fields J Z, Gordon J H
Life Sci. 1982 Jan 18;30(3):229-34. doi: 10.1016/0024-3205(82)90503-3.
Administration of estrogen to rats during the period of withdrawal from chronic haloperidol attenuated the characteristic increase in apomorphine-induced stereotypy and the increase in (3H) spiroperidol binding. This apparent ability of estrogen to "down-regulate" brain dopamine receptors could lead to useful pharmacological treatments of tardive dyskinesia and possibly of other hyperdopaminergic states.
