Mabray C R, Burditt M L, Martin T L, Jaynes C R, Hayes J R
Obstet Gynecol. 1982 May;59(5):560-4.
The technique of managing allergies by optimum-dose (provocative neutralization) testing and treatment using aqueous progesterone has been studied in 132 women having progesterone-related symptoms due to the menstrual cycle, pregnancy, or exogenous hormone administration. When extremely small doses of progesterone (0.0016 mg or below, up to maximum of 2.5 mg) were administered following determination of specific dose requirement by skin testing, startlingly rapid and effective clearing of symptoms was observed. With these individualized doses, symptoms cleared completely or almost completely within 30 minutes in the majority of patients. A single-blind technique was employed to rule out placebo effect. Some common problems found to respond well to the procedure were nausea and vomiting during pregnancy (100%), premenstrual syndrome (96%), and dysmenorrhea (84%).
通过最佳剂量(激发中和)测试以及使用水性孕酮进行治疗来管理过敏的技术,已在132名因月经周期、怀孕或外源性激素给药而出现与孕酮相关症状的女性中进行了研究。在通过皮肤测试确定特定剂量需求后,给予极小剂量的孕酮(0.0016毫克或更低,最大剂量为2.5毫克)时,观察到症状惊人地迅速且有效地消除。使用这些个体化剂量时,大多数患者的症状在30分钟内完全或几乎完全消除。采用单盲技术以排除安慰剂效应。发现对该程序反应良好的一些常见问题包括孕期恶心和呕吐(100%)、经前综合征(96%)和痛经(84%)。