Mehlhorn H, Steinhorst U, Lindenblatt B, Grüntzig J, Thomas H
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981 Dec;251(2):263-72.
Microfilariae of Dipetalonema viteae and Litomosoides carinii were studied by means of electron microscopy after oral treatment of their hosts with metrifonate (3 x 100 mg/kg) or diethylcarbamazine (3 x 250 mg/kg). These dosages led to the disappearance of microfilariae from the peripheral venous blood. However, in numerous organs blood capillaries or interstitial spaces contained degenerating microfilariae. In these cases the cytoplasm of the microfilarian cells was completely lysed, whereas the cuticle seemed to be unaffected, at least initially. Microfilariae of both species were also often found intracellularly especially in liver and muscle cells after application of both drugs. The intracellular microfilariae, however, had fewer or even no lesions, suggesting that they might escape the activity of the drug.
在用敌百虫（3×100毫克/千克）或乙胺嗪（3×250毫克/千克）口服处理其宿主后，利用电子显微镜对魏氏双瓣线虫和卡里尼丝虫的微丝蚴进行了研究。这些剂量导致外周静脉血中微丝蚴消失。然而，在许多器官的毛细血管或间质间隙中含有正在退化的微丝蚴。在这些情况下，微丝蚴细胞的细胞质完全溶解，而角质层似乎至少在最初未受影响。在应用这两种药物后，两种线虫的微丝蚴也经常在细胞内被发现，尤其是在肝细胞和肌肉细胞中。然而，细胞内的微丝蚴损伤较少甚至没有损伤，这表明它们可能逃避了药物的作用。
