Wold L E, Unni K K, Beabout J W, Ivins J C, Bruckman J E, Dahlin D C
Am J Surg Pathol. 1982 Jan;6(1):59-70. doi: 10.1097/00000478-198201000-00006.
Hemangioendothelial sarcoma of bone is a rare tumor. A series of 112 cases was studied to define the clinical and pathologic features of this disease. Of the various histologic features evaluated to define the ones most significant prognostically, the histologic grade of the lesions was the single feature that correlated best with disease-free survival. In this series, patients with multi-focal tumors did not have a better prognosis than patients with unicentric disease. Surgery remains the primary treatment for these patients. Radiotherapy may be useful for surgically inaccessible lesions of the axial skeleton. Too few patients have received adjuvant chemotherapy to evaluate its usefulness in this setting.
骨血管内皮肉瘤是一种罕见的肿瘤。对112例病例进行了研究，以明确该疾病的临床和病理特征。在评估的各种组织学特征中，为确定哪些特征在预后方面最为显著，病变的组织学分级是与无病生存期相关性最佳的单一特征。在本系列研究中，多灶性肿瘤患者的预后并不优于单中心疾病患者。手术仍然是这些患者的主要治疗方法。放疗可能对轴向骨骼中手术难以触及的病变有用。接受辅助化疗的患者太少，无法评估其在这种情况下的效用。
