Kiricuta I, Frenkel Z
Arch Geschwulstforsch. 1982;52(1):67-73.
The main endocrine features in a group of 87 patients with inflammatory breast carcinoma with very rapid evolution (group I) and those of 400 patients with breast cancer with no inflammatory signs (group II) have been compared. The mean age at menarche showed a significantly higher degree in group I, where the later menarche was reported in 36.8% of cases (greater than or less than 16 years). The mean number of abortions has been decreased in the same groups. No significant differences regarding to parity, lactation and mean age of the menopause have been found in these two groups. The mean values for total urinary estrogens were significantly higher in group I. The main fractions of 17-ketosteroids were estimated in 60 women of group I and 61 women of group II. The mean levels of these hormones were more decreased in group I, the most significantly differences in these two groups were registered for ethiocholanolone. In the most cases with decreased levels of ethiocholanolone, the survival time was also shorter. Such data showed a more prominent endocrine imbalance in the inflammatory breast carcinoma in comparison with breast cancer patients of normal evolution.
对87例具有非常快速进展的炎性乳腺癌患者（第一组）和400例无炎症体征的乳腺癌患者（第二组）的主要内分泌特征进行了比较。第一组月经初潮的平均年龄显著更高，其中36.8%的病例月经初潮较晚（大于或小于16岁）。相同组中流产的平均次数有所减少。在这两组中，关于产次、哺乳情况和绝经平均年龄未发现显著差异。第一组总尿雌激素的平均值显著更高。对第一组的60名女性和第二组的61名女性进行了17-酮类固醇的主要成分分析。第一组中这些激素的平均水平下降得更多，两组中最显著的差异出现在本胆烷醇酮方面。在大多数本胆烷醇酮水平降低的病例中，生存时间也较短。这些数据表明，与病情正常进展的乳腺癌患者相比，炎性乳腺癌存在更明显的内分泌失衡。
