Mendlewicz J
J Genet Hum. 1981 Dec;29(5 Suppl):527-33.
In this article, the part of hereditary factors in the onset of depressive diseases is analysed. Primary depressive diseases may be now separated in two groups: one includes bipolar depressive syndromes. (e.i. of manic depressive type) and the other the monopolar depressive syndromes (e.i. of depressive type). A short review of twin studies and family studies in the manic depressive type bipolar depressive illnesses is made. From these studies, a discussion about genetical hypothesis concerning the manic depressive illnesses is proposed. Different genetical hypotheses are revisited, and that of a dominant X-linked disease is observed. Genetical factors are also revisited into the heterogeneous group of monopolar depressive diseases, emphasizing the different depressive subgroups of this large category. Finally, the authors also consider the possible relationship between bipolar manic depressive syndromes and schizophrenia, trying to classify the dysthymic schizophrenia.
本文分析了遗传因素在抑郁症发病中的作用。原发性抑郁症目前可分为两组：一组包括双相抑郁综合征（即躁狂抑郁型），另一组为单相抑郁综合征（即抑郁型）。本文对双相躁狂抑郁型疾病的双胞胎研究和家族研究进行了简要回顾。基于这些研究，提出了关于躁狂抑郁性疾病的遗传假说。文中重新审视了不同的遗传假说，并观察到一种X连锁显性疾病的假说。遗传因素也在单相抑郁疾病的异质性组中进行了重新审视，强调了这一大类中不同的抑郁亚组。最后，作者还考虑了双相躁狂抑郁综合征与精神分裂症之间的可能关系，试图对心境恶劣性精神分裂症进行分类。
