流感嗜血杆菌脑膜炎中的眼阵挛

Opsoclonus in Hemophilus influenzae meningitis.

作者信息

Rivner M H, Jay W M, Green J B, Dyken P R

出版信息

Neurology. 1982 Jun;32(6):661-3. doi: 10.1212/wnl.32.6.661.

DOI:10.1212/wnl.32.6.661

PMID:7201096

Abstract

We studied a 3-month-old boy who had opsoclonus in association with acute bacterial meningitis. The CSF IgG and IgM were elevated acutely, gradually returning to normal with clinical improvement. Correspondingly, CSF cytomorphology showed excessive plasmocytosis and a higher proportion of reactive lymphocytes than expected in an acute bacterial meningitis. These abnormalities in CSF cytology are effects of an abnormal immune response in the CNS, and provide evidence to support an immunopathic basis to opsoclonus.

摘要

我们研究了一名3个月大患有眼阵挛并伴有急性细菌性脑膜炎的男童。脑脊液中的免疫球蛋白G（IgG）和免疫球蛋白M（IgM）急性升高，随着临床症状改善逐渐恢复正常。相应地，脑脊液细胞形态学显示浆细胞增多，且反应性淋巴细胞比例高于急性细菌性脑膜炎的预期。脑脊液细胞学的这些异常是中枢神经系统异常免疫反应的结果，为眼阵挛的免疫病理基础提供了支持证据。