梅杰氏病：急性和慢性胆碱能效应。

Meige disease: acute and chronic cholinergic effects.

作者信息

Tanner C M, Glantz R H, Klawans H L

出版信息

Neurology. 1982 Jul;32(7):783-5. doi: 10.1212/wnl.32.7.783.

DOI:10.1212/wnl.32.7.783

PMID:7201118

Abstract

We studied central cholinergic systems in 13 patients with idiopathic adult-onset blepharospasm/oromandibular dystonia (Meige syndrome). Six patients studied acutely, and 12 of 13 patients studied chronically, improved after administration of centrally acting anticholinergic agents. These data suggest that Meige syndrome is pharmacologically similar to other dystonic disorders, in which central cholinergic antagonism is more consistently of benefit than manipulation of central dopaminergic systems.

摘要

我们研究了13例特发性成人起病的眼睑痉挛/口下颌肌张力障碍（梅杰综合征）患者的中枢胆碱能系统。6例患者接受了急性研究，13例患者中的12例接受了长期研究，在给予中枢作用的抗胆碱能药物后病情有所改善。这些数据表明，梅杰综合征在药理学上与其他肌张力障碍疾病相似，在其他肌张力障碍疾病中，中枢胆碱能拮抗作用比调节中枢多巴胺能系统更具持续疗效。