肉毒杆菌毒素治疗对神经源性睑痉挛的影响。
Effect of treatment with botulinum toxin on neurogenic blepharospasm.
作者信息
Elston J S, Russell R W
出版信息
Br Med J (Clin Res Ed). 1985 Jun 22;290(6485):1857-9. doi: 10.1136/bmj.290.6485.1857.
Abstract
Botulinum toxin type A creates temporary localised flaccid paralysis after injection into skeletal muscle. Thirty four patients with blepharospasm, of whom 28 also had the oromandibular dystonia syndrome, were treated with injections of botulinum toxin type A into the orbicularis oculi, and 28 showed functional improvement after the treatment. A high incidence of local side effects occurred, especially partial ptosis, which was well tolerated. There were no systemic side effects. The average period of relief was 2.5 months, increasing to 2.8 months after a second injection. Functional improvement was limited in patients with severe associated dystonia.
摘要
A型肉毒杆菌毒素注射到骨骼肌后会造成局部暂时弛缓性麻痹。34例睑痉挛患者（其中28例还患有口下颌肌张力障碍综合征）接受了眼轮匝肌注射A型肉毒杆菌毒素治疗，28例治疗后功能改善。局部副作用发生率高，尤其是上睑下垂，但耐受性良好。无全身副作用。平均缓解期为2.5个月，第二次注射后增至2.8个月。伴有严重肌张力障碍的患者功能改善有限。
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