Raj S G, Raj M H, Talbert L M, Sloan C S, Hicks B
Obstet Gynecol. 1982 Jul;60(1):15-9.
Oral contraceptives reduce the elevated androgen levels in polycystic ovary disease. However, treatment with oral contraceptives is associated with undesirable side effects because of their high estrogen content. This study was undertaken to examine the effects of low estrogen-containing oral contraceptive (Loestrin:norethindrone acetate 1.5 mg and ethinyl estradiol 30 micrograms) on 25 women with polycystic ovary disease of ovarian origin. Loestrin treatment normalized the elevated luteinizing hormone and total and unbound testosterone levels and increased testosterone binding globulin levels. In a time-course study, unbound testosterone declined within a week of initiating treatment and by 12 to 16 weeks was completely normal. Reduction in hair growth and improvement in complexion were noted by about 12 to 16 weeks. Side effects of treatment were minimal.
口服避孕药可降低多囊卵巢病中升高的雄激素水平。然而，由于其高雌激素含量，口服避孕药治疗会伴有不良副作用。本研究旨在检测低雌激素口服避孕药（炔诺酮醋酸酯1.5毫克和炔雌醇30微克）对25名卵巢源性多囊卵巢病女性的影响。炔诺酮治疗使升高的促黄体生成素、总睾酮和游离睾酮水平恢复正常，并提高了睾酮结合球蛋白水平。在一项时间进程研究中，游离睾酮在开始治疗一周内下降，到12至16周时完全恢复正常。在约12至16周时，观察到毛发生长减少和面色改善。治疗的副作用极小。
