De Souza H, Palermo-Neto J
Pharmacology. 1982;24(4):222-9. doi: 10.1159/000137600.
The effects of cholinergic (Ach) and anti-Ach drugs on stereotyped behavior induced by apomorphine administration were studied quantitatively. Dose-response curves were constructed to apomorphine and the horizontal shifts of the experimental curves induced by the different treatments were measured at the level of ED50 of apomorphine. Treatment with both atropine sulfate and scopolamine hydrobromide induced a leftward displacement of the dose-response curve; physostigmine and oxotremorine displaced the curve to the right. Changes in stereotypy were not observed after atropine methyl nitrate. It is concluded that the activity of acetylcholine-containing neurons may exert a modulatory influence on dopaminergic systems.
定量研究了胆碱能（乙酰胆碱）和抗胆碱药物对阿扑吗啡诱导的刻板行为的影响。构建了阿扑吗啡的剂量-反应曲线，并在阿扑吗啡的半数有效剂量（ED50）水平测量了不同处理诱导的实验曲线的水平位移。硫酸阿托品和氢溴酸东莨菪碱处理均导致剂量-反应曲线向左位移；毒扁豆碱和氧化震颤素使曲线向右位移。硝酸甲基阿托品处理后未观察到刻板行为的变化。结论是，含乙酰胆碱的神经元的活性可能对多巴胺能系统发挥调节作用。
