长期乙醇摄入对大鼠腹腔巨噬细胞的影响。
Effects of long-term ethanol consumption on rat peritoneal macrophages.
作者信息
Mørland B, Mørland J
出版信息
Acta Pharmacol Toxicol (Copenh). 1982 Mar;50(3):221-4. doi: 10.1111/j.1600-0773.1982.tb00965.x.
Abstract
Rats were fed an all liquid diet for 7-8 weeks. One group received 35% of the calories as ethanol while the other group was pair-fed carbohydrates. Peritoneal macrophages prepared from ethanol treated rats had lower phagocytosis via the Fe-receptor and reduced viability in the presence of endotoxin, but their lysosomal enzyme activities measured (beta-glucuronidase, cathepsin D, acid phosphatase and acid DNase) were not different from controls.
摘要
大鼠接受全液体饮食7 - 8周。一组摄入的热量中有35%来自乙醇，而另一组则以碳水化合物进行配对喂养。从经乙醇处理的大鼠制备的腹腔巨噬细胞通过铁受体的吞噬作用较低，并且在内毒素存在的情况下活力降低，但其测得的溶酶体酶活性（β - 葡萄糖醛酸酶、组织蛋白酶D、酸性磷酸酶和酸性脱氧核糖核酸酶）与对照组无差异。
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