乙醇摄入及戒断对小鼠骨髓中B细胞亚群的影响。
Effects of ethanol consumption and withdrawal on B cell subpopulations in murine bone marrow.
作者信息
Kruger T E, Jerrells T R
机构信息
Department of Cellular Biology and Anatomy, Louisiana State University Medical Center, Shreveport 71130.
出版信息
Clin Exp Immunol. 1994 Jun;96(3):521-7. doi: 10.1111/j.1365-2249.1994.tb06060.x.
We designed studies to examine the effects of ethanol consumption and withdrawal on the numbers of pre-B and B cells in murine bone marrow. Flow cytometric analysis of B220 and surface IgM expression on bone marrow cells revealed that consumption of ethanol by mice for 7 days led to a significant reduction in pre-B cells. The number of mature B cells in the bone marrow of these animals, however, did not differ from that of control mice. In contrast, examination of bone marrow obtained from mice at various times after withdrawal from ethanol showed significantly fewer numbers of mature B cells and an even greater loss of pre-B cells. This effect was seen for relatively long periods after withdrawal. These study findings are interpreted to suggest that ethanol consumption results in changes in the pre-B cell population in murine bone marrow. It also appears that withdrawal from ethanol results in more profound changes in the mature B cell population of the bone marrow than those that occur during ethanol consumption.
我们设计了多项研究来检验乙醇摄入及戒断对小鼠骨髓中前B细胞和B细胞数量的影响。对骨髓细胞上B220和表面IgM表达进行的流式细胞术分析显示，小鼠摄入乙醇7天会导致前B细胞显著减少。然而，这些动物骨髓中成熟B细胞的数量与对照小鼠并无差异。相比之下，对乙醇戒断后不同时间点的小鼠骨髓进行检查发现，成熟B细胞数量显著减少，前B细胞损失更为严重。这种效应在戒断后的较长时间内都能观察到。这些研究结果被解释为表明乙醇摄入会导致小鼠骨髓中前B细胞群体发生变化。似乎乙醇戒断导致骨髓中成熟B细胞群体发生的变化比乙醇摄入期间更为显著。
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