Tanner G
Anesth Analg. 1982 Jul;61(7):587-94.
The evolution of mathematical models of the uptake of the inhaled anesthetic agents has produced increasingly complex models in which researchers have attempted to incorporate more and more data on the effects of anesthetics on the processes of respiration, circulation, and metabolism. One result of this evolution has been to limit the application of these models due to the large amount of data required by the model and the need for a large digital computer to generate a solution. The purpose of this study is to show that a three-compartment linear model, using only the solubility of an anesthetic in water and oil, may br used to predict the uptake of a volatile anesthetic with sufficient accuracy for practical purposes. Only a programmable hand calculator is needed for the solution. Due to the simplicity of this model, compared with previously described models, it should prove useful in understanding the kinetics of gas uptake by the body.
吸入麻醉剂摄取数学模型的发展产生了日益复杂的模型，在这些模型中，研究人员试图纳入越来越多关于麻醉剂对呼吸、循环和代谢过程影响的数据。这种发展的一个结果是，由于模型所需的数据量很大，并且需要大型数字计算机来生成解决方案，限制了这些模型的应用。本研究的目的是表明，一个仅使用麻醉剂在水和油中的溶解度的三室线性模型，可用于以足够的精度预测挥发性麻醉剂的摄取，以满足实际应用。求解仅需要一台可编程手持计算器。由于该模型与先前描述的模型相比很简单，它应该在理解身体对气体摄取的动力学方面证明是有用的。
