Falk P
Eur J Cancer Clin Oncol. 1982 Feb;18(2):155-65. doi: 10.1016/0277-5379(82)90059-1.
The transplanted C3H tumor differs from the spontaneous in its multi-focal origin and in its increasing loss of differentiation. Loss of differentiation is principally important in that even the partial branching into lobes, which occurs in the spontaneous tumour, is lost and that the parenchyma no longer consists of single-layered and multi-layered tubules, as in the spontaneous tumour, but of multi-layered only. Absence of branching removes the interlobular pressures, which in spontaneous tumours lead to infarction of the efferent vessels and sinus formation. Consequently; sinuses are absent from the transplanted tumour and the circulation is thereby improved. In contrast, since the vascular pattern of the spontaneous tumour is preserved and capillaries do not penetrate into the multi-layered tubules, although these have developed into solid cylinders, the diffusion pathway of oxygen is extended, resulting in necrosis at their cores. Accumulating necrotic fluid is at first removed by lymphatics, but subsequently invades the efferent vascular system. These changes are reflected in the pattern of tumour growth and in the radiation responses.
移植的C3H肿瘤与其自发肿瘤的不同之处在于其多灶性起源以及分化程度的不断降低。分化程度降低主要体现在，自发肿瘤中出现的部分向叶状分支的情况消失了，而且实质不再像自发肿瘤那样由单层和多层小管组成，而是仅由多层小管组成。分支的缺失消除了小叶间压力，而在自发肿瘤中，这种压力会导致输出血管梗死和窦形成。因此，移植肿瘤中没有窦，从而改善了血液循环。相比之下，由于自发肿瘤的血管模式得以保留，尽管多层小管已发展成实心圆柱体，但毛细血管并未穿透其中，导致氧气扩散路径延长，进而在其核心部位发生坏死。起初，积聚的坏死液体会通过淋巴管清除，但随后会侵入输出血管系统。这些变化反映在肿瘤生长模式和放射反应中。
