Bertoni J M
Neurology. 1982 Aug;32(8):884-7. doi: 10.1212/wnl.32.8.884.
The myelographic contrast agent, metrizamide, causes a temporary confusional state in many patients. Since metrizamide is a 2-deoxyglucose analogue, it was tested for inhibitory effects on glucose metabolism. The Michaelis constant (Km) of human brain hexokinase for glucose rose from 0.039 to 0.24 and 0.47 mM with final metrizamide concentrations of 0, 16 and 32 mM, respectively. The maximal velocity did not change. Since metrizamide is injected into the human CSF in concentrations of up to 780 mM, impairment of brain glucose metabolism can be expected. These effects could be largely counteracted if metrizamide were injected in a 100 mM glucose solution.
脊髓造影剂甲泛葡胺会使许多患者出现短暂的意识模糊状态。由于甲泛葡胺是一种2-脱氧葡萄糖类似物，因此对其对葡萄糖代谢的抑制作用进行了测试。人脑己糖激酶对葡萄糖的米氏常数（Km）在甲泛葡胺终浓度分别为0、16和32 mM时，从0.039升至0.24和0.47 mM。最大反应速度未改变。由于甲泛葡胺以高达780 mM的浓度注入人体脑脊液中，因此可以预期会损害脑葡萄糖代谢。如果将甲泛葡胺注入100 mM的葡萄糖溶液中，这些影响在很大程度上可以得到抵消。
