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癫痫和头痛中的小脑萎缩:与苯妥英钠无关。

Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin.

作者信息

Ballenger C E, Lucke J F, King D W, El Gammal T, Brooks B S, Green J B

出版信息

Neurology. 1982 Aug;32(8):910-2. doi: 10.1212/wnl.32.8.910.

DOI:10.1212/wnl.32.8.910
PMID:7201589
Abstract

CT scans of 70 patients with seizures and 48 patients with headaches were studied. Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself. We found no evidence that either phenytoin or epilepsy caused cerebellar atrophy.

摘要

对70例癫痫患者和48例头痛患者进行了CT扫描研究。根据公认的小脑萎缩诊断CT标准,以盲法、无偏倚的方式对扫描片进行分析,以评估小脑萎缩与苯妥英使用或癫痫本身之间的可能关系。我们没有发现证据表明苯妥英或癫痫会导致小脑萎缩。

相似文献

1
Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin.癫痫和头痛中的小脑萎缩:与苯妥英钠无关。
Neurology. 1982 Aug;32(8):910-2. doi: 10.1212/wnl.32.8.910.
2
Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy.长期服用苯妥英钠且患有癫痫的患者出现小脑萎缩。
Arch Neurol. 1994 Aug;51(8):767-71. doi: 10.1001/archneur.1994.00540200043014.
3
[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy].[癫痫患者长期使用苯妥英钠与小脑萎缩的剂量依赖关系]
Arq Neuropsiquiatr. 2000 Jun;58(2A):276-81. doi: 10.1590/s0004-282x2000000200012.
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Cerebellar atrophy following diphenylhydantoin intoxication.
Neuropediatrics. 1984 May;15(2):76-81. doi: 10.1055/s-2008-1052345.
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[Cerebellar atrophy in epileptic patients: computer tomography study].
Fortschr Neurol Psychiatr. 1985 Dec;53(12):437-41. doi: 10.1055/s-2007-1001989.
6
[Temporal cerebellar atrophy following phenytoin therapy].苯妥英治疗后小脑的颞叶萎缩
Neurologia. 1997 Jun-Jul;12(6):259-61.
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Cerebellar atrophy in epileptic patients.
Can J Neurol Sci. 1988 Aug;15(3):299-303. doi: 10.1017/s0317167100027785.
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[Residual cerebellar ataxia following acute phenytoin intoxication].[急性苯妥英中毒后的残留小脑共济失调]
Rev Neurol (Paris). 1999 Apr;155(4):306-8.
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Cerebellar atrophy in phenytoin-treated mentally retarded epileptics.
Epilepsia. 1977 Sep;18(3):375-86. doi: 10.1111/j.1528-1157.1977.tb04980.x.
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The cerebellum of epileptics.癫痫患者的小脑。
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引用本文的文献

1
Cerebellar Degeneration in Epilepsy: A Systematic Review.癫痫性小脑变性:系统评价。
Int J Environ Res Public Health. 2021 Jan 8;18(2):473. doi: 10.3390/ijerph18020473.
2
The nature and extent of cerebellar atrophy in chronic temporal lobe epilepsy.慢性颞叶癫痫患者小脑萎缩的性质和程度。
Epilepsia. 2011 Apr;52(4):698-706. doi: 10.1111/j.1528-1167.2010.02937.x. Epub 2011 Jan 26.
3
Cerebellar injury due to phenytoin. Identification and evolution of Purkinje cell axonal swellings in deep cerebellar nuclei of mice.
苯妥英所致的小脑损伤。小鼠小脑深部核团中浦肯野细胞轴突肿胀的识别与演变。
Acta Neuropathol. 1989;77(3):289-98. doi: 10.1007/BF00687581.