Bogolepov N N, Verbitskaia L B, Belova T I, Sudakov K V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82(5):51-4.
The ultrastructure of the neurones and synapses of the parietal area of the cortex and reticular formation of the brain of rats was studied after emotional stress induced by 2-hour immobilization, as well as 1 and 24 hours after discontinuance of immobilization. Two types of ultrastructural changes were revealed. Some of the changes were reversible and functional in nature and were largely pertinent to the alterations on the cytoplasma part, with these alterations being appreciably reduced 24 hours after the discontinuance of immobilization. The other ones (vacuolization of neuronal nuclei and marked changes in the synapses) were more pronounced and resistant and were seen 24 hours after the immobilization was discontinued. It is suggested that stable changes that do not disappear 24 hours after the immobilization stress might form the pathomorphological basis for the clinical syndromes of cerebrovisceral disorders that develop during long-term periods after the stress.
在对大鼠进行2小时固定诱导的情绪应激后，以及在停止固定1小时和24小时后，对其大脑皮质顶叶区域和网状结构的神经元及突触的超微结构进行了研究。揭示了两种类型的超微结构变化。一些变化本质上是可逆的且具有功能性，主要与细胞质部分的改变有关，在停止固定24小时后这些改变明显减少。另一些变化（神经元核空泡化和突触的显著变化）则更为明显且具有抗性，在停止固定24小时后仍可见到。有人认为，在固定应激后24小时仍未消失的稳定变化可能构成应激后长期出现的脑内脏疾病临床综合征的病理形态学基础。
