[Synthesis of 4-ureidooxycyclophosphamide (author's transl)].
作者信息
Niemeyer U, Scheffler G, Nonnenmacher G
出版信息
Arzneimittelforschung. 1982;32(5):478-80.
PMID:7201822
Abstract
The synthesis of 4-ureidooxycyclophosphamide, a potential cytostatic, whose cis/trans-isomers can be stereoselectively obtained from 4-hydroxycyclophosphamide and hydroxyurea in DMF in DMF or water, is described. These compounds are remarkably stable at room temperature. For the first time, the two epimers from a derivative of 4-hydroxycyclophosphamide can be NMR-spectroscopically compared with each other.
摘要
相似文献
1
[Synthesis of 4-ureidooxycyclophosphamide (author's transl)].
Arzneimittelforschung. 1982;32(5):478-80.
2
Studies on 4-hydroperoxycyclophosphamide (NSC-181815): a simple preparation method and its application for the synthesis of a new class of "activated" sulfur-containing cyclophosphamide (NSC-26271) derivatives.4-氢过氧环磷酰胺（NSC-181815）的研究：一种简单的制备方法及其在合成新型“活性”含硫环磷酰胺（NSC-26271）衍生物中的应用。
Cancer Treat Rep. 1976 Apr;60(4):429-35.
3
Isolation and identification of a stabilized derivative of aldophosphamide, a major metabolite of cyclophosphamide.
Cancer Res. 1974 Nov;34(11):2933-5.
4
Aldophosphamide: synthesis, characterization, and comparison with "Hohorst's aldophosphamide".
Cancer Treat Rep. 1976 Apr;60(4):317-9.
5
NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathways.环磷酰胺中间代谢产物的核磁共振光谱研究。顺式和反式4-羟基环磷酰胺与醛磷酰胺相互转化以及醛磷酰胺在不可逆裂解和可逆共轭途径之间伴随分配的综合动力学分析。
J Med Chem. 1984 Apr;27(4):466-85. doi: 10.1021/jm00370a008.
6
Synthesis and preliminary antitumor evaluation of 4-(SR)-sulfido-cyclophosphamides.4-(SR)-硫代环磷酰胺的合成及初步抗肿瘤评价
Cancer Chemother Pharmacol. 1979;3(3):181-8. doi: 10.1007/BF00262420.
7
[Potential virostatics. Part 3: NMR Studies in quinoxalines and s-triazolo (4,3-a) quinoxalines (author's transl)].
Pharmazie. 1980 Feb;35(2):84-6.
8
The mechanism of activation of 4-hydroxycyclophosphamide.
J Med Chem. 1987 Feb;30(2):427-31. doi: 10.1021/jm00385a029.
9
X-ray crystallographic studies of cyclophosphamide (NSC-26271) derivatives.
Cancer Treat Rep. 1976 Apr;60(4):517-22.
Zotero 插件