Barbaccia M L, Bosio A, Lucchi L, Spano P F, Trabucchi M
Life Sci. 1982 Jun 21;30(25):2163-70. doi: 10.1016/0024-3205(82)90290-9.
Chronic ethanol consumption induces an increase in striatal 3H-Spiroperidol and 3H(-)Sulpiride specific binding by enhancing the affinity between the different dopaminergic recognition sites and the labelled ligands. Dopamine (DA) receptor supersensitivity is also suggested by the enhanced effect of neuroleptics in inducing hypomotility in rats treated with ethanol. The results, obtained by means of the administration of neuroleptics in comparison to ethanol treated rats, indicate a lack of cross tolerance between ethanol and other drugs acting on the dopaminergic recognition sites. These data suggest that ethanol effects on the dopaminergic system are mediated by events involving other neurotransmitter systems.
长期摄入乙醇会通过增强不同多巴胺能识别位点与标记配体之间的亲和力，导致纹状体中3H-螺哌啶醇和3H（-）舒必利特异性结合增加。用乙醇处理的大鼠中，抗精神病药物诱导运动减少的作用增强，这也提示了多巴胺（DA）受体超敏反应。与乙醇处理的大鼠相比，通过给予抗精神病药物获得的结果表明乙醇与作用于多巴胺能识别位点的其他药物之间不存在交叉耐受性。这些数据表明，乙醇对多巴胺能系统的影响是由涉及其他神经递质系统的事件介导的。
