乙醇与多巴胺能系统

Ethanol and dopaminergic systems.

作者信息

Lucchi L, Lupini M, Govoni S, Covelli V, Spano P F, Trabucchi M

出版信息

Pharmacol Biochem Behav. 1983;18 Suppl 1:379-82. doi: 10.1016/0091-3057(83)90203-4.

Abstract

Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the production of cyclic AMP. This finding demonstrates that the dopaminergic receptor associated with adenylate-cyclase activity is affected by chronic ethanol treatment. In particular, the affinity of the dopaminergic receptor labelled by 3H-Spiperone is enhanced. In addition, the receptor-adenylate cyclase coupling system is impaired after chronic in vivo exposure of animals to ethanol.

摘要

长期摄入乙醇会导致细胞膜结构紊乱，可能是通过改变膜脂质含量来实现的。这种损害会导致与膜相关的过程发生改变。事实上，在长期接触乙醇后，纹状体腺苷酸环化酶的活性会增加。另一方面，多巴胺无法进一步增强环磷酸腺苷（cAMP）的生成。这一发现表明，与腺苷酸环化酶活性相关的多巴胺能受体受到长期乙醇处理的影响。特别是，被3H-螺哌隆标记的多巴胺能受体的亲和力增强。此外，动物在体内长期接触乙醇后，受体-腺苷酸环化酶偶联系统会受损。