Petty F, Sacquitne J L, Sherman A D
Neuropharmacology. 1982 May;21(5):475-7. doi: 10.1016/0028-3908(82)90034-x.
In the behavioral reversal of learned helplessness in the rat by imipramine, a strong correlation is found between "cure" of helplessness and drug level in anterior neocortex, the locus of drug action in this model of depression. This suggests that the delayed onset of therapeutic action of antidepressant drugs is due to the time required to achieve adequate drug levels at the site of their action.
在通过丙咪嗪使大鼠习得性无助行为发生逆转的过程中，发现无助行为的“治愈”与前新皮质中的药物水平之间存在很强的相关性，而前新皮质是该抑郁症模型中药物作用的位点。这表明抗抑郁药物治疗作用的延迟起效是由于在其作用位点达到足够药物水平所需的时间。
