杜氏肌营养不良症和甲型血友病的基因连锁研究。
Genetic linkage study of Duchenne muscular dystrophy and hemophilia A.
作者信息
Konagaya M, Takayanagi T, Kamiya T, Takamatsu S
出版信息
Neurology. 1982 Sep;32(9):1046-9. doi: 10.1212/wnl.32.9.1046.
PMID:7202158
Abstract
We studied a family in which three boys had both Duchenne muscular dystrophy and hemophilia A. Seven other males had only hemophilia A. Genetic linkage study showed a maximum likelihood estimate of recombination frequency of these two X-linked recessive traits of 0.16 with 95% confidence limits of 0.045 and 0.50. The loci of the two diseases may be closer than previous estimates.
摘要
我们研究了一个家庭，其中三个男孩同时患有杜氏肌营养不良症和甲型血友病。另外七个男性仅患有甲型血友病。基因连锁研究表明，这两种X连锁隐性性状的重组频率的最大似然估计值为0.16，95%置信区间为0.045至0.50。这两种疾病的基因座可能比之前估计的更近。
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