Michanek A, Meyerson B J
Pharmacol Biochem Behav. 1982 Jun;16(6):875-9. doi: 10.1016/0091-3057(82)90039-9.
A study was made of the influence of apomorphine. D- and L-amphetamine on the effects of different hormonal treatments used to induce copulatory behavior in female rats. Female copulatory behavior, (lordosis response), which has been shown to be inhibited by increased DA and 5-HT neuronal activity, was depressed by apomorphine, D- and L-amphetamine in ovariectomized rats treated with estrogen + progesterone. When lordosis behavior was activated by estrogen alone the inhibitory action of the drugs, especially that of apomorphine was considerably less pronounced. However, the effect of D-amphetamine on stereotype activity was not greater after treatment with estrogen + progesterone than after administration of estrogen alone. Estrogen had a slight stimulatory effect on stereotype activity in non-drug-treated rats, while progesterone had an inhibitory effect. Possible mechanisms underlying the observed interactive effect of progesterone and monoamines on lordosis behavior, such as a progesterone-induced alteration of monoaminergic transmission, are discussed.
研究了阿扑吗啡、D-和L-苯丙胺对用于诱导雌性大鼠交配行为的不同激素处理效果的影响。已证明增加多巴胺（DA）和5-羟色胺（5-HT）神经元活性会抑制雌性交配行为（脊柱前凸反应），在接受雌激素+孕酮治疗的去卵巢大鼠中，阿扑吗啡、D-和L-苯丙胺会抑制这种行为。当单独使用雌激素激活脊柱前凸行为时，药物的抑制作用，尤其是阿扑吗啡的抑制作用明显减弱。然而，与单独给予雌激素相比，在接受雌激素+孕酮治疗后，D-苯丙胺对刻板行为的影响并没有更大。在未用药物处理的大鼠中，雌激素对刻板行为有轻微的刺激作用，而孕酮有抑制作用。文中讨论了孕酮和单胺对脊柱前凸行为的相互作用效应的潜在机制，例如孕酮诱导的单胺能传递改变。
