Savageau M M, Beatty W W
Pharmacol Biochem Behav. 1981 Jan;14(1):17-21. doi: 10.1016/0091-3057(81)90097-6.
Following treatment with 5 mg/kg d-amphetamine sulfate or 2 mg/kg apomorphine hydrochloride female rats displayed more intense and longer lasting stereotyped behavior than males. Gonadectomy did not affect the display of stereotyped behavior induced by either drug in either sex. A lower dose of amphetamine (1 md/kg) caused greater stimulation of locomotor activity in females than in males. Castration of males had no effect, but ovariectomy blocked the stimulating effect of amphetamine on activity. By contrast, low doses of apomorphine depressed activity in a dose-dependent manner that was somewhat greater in ovariectomized females than in the other groups. These data add to the growing body of literature demonstrating that gonadal hormones modulate the activity of brain dopamine systems.
用5毫克/千克硫酸右旋苯丙胺或2毫克/千克盐酸阿扑吗啡处理后，雌性大鼠比雄性大鼠表现出更强烈、更持久的刻板行为。性腺切除术对两种药物在任一性别中诱导的刻板行为表现均无影响。较低剂量的苯丙胺（1毫克/千克）对雌性运动活动的刺激作用大于雄性。雄性去势没有影响，但卵巢切除阻断了苯丙胺对活动的刺激作用。相比之下，低剂量的阿扑吗啡以剂量依赖的方式抑制活动，在去卵巢雌性大鼠中这种抑制作用比其他组稍大。这些数据进一步丰富了现有文献，表明性腺激素调节脑多巴胺系统的活性。
