Katz R J, Baldrighi G
Pharmacol Biochem Behav. 1982 Jun;16(6):969-72. doi: 10.1016/0091-3057(82)90054-5.
We have proposed that chronic stress may produce motivational, behavioral, and neuroendocrine symptoms in rats resembling endogenous depression in humans. The chronic stress model has proved responsive to chronic treatment by antidepressant drugs. Two issues concerning this effect remain unresolved, these being; the requirement of drug chronicity, and treatment outcome to different drug doses. The present experiment examined both issues in a factorial design in which vehicle and two doses of the tricyclic antidepressant imipramine were varied across 2 treatment periods; acute (1 hr) and chronic (3 weeks). Both factors were found to significantly interact with treatment outcome, suggesting that chronic treatment is necessary for recovery and that this outcome is dependent upon drug level.
我们已经提出，慢性应激可能会在大鼠身上产生类似于人类内源性抑郁症的动机、行为和神经内分泌症状。慢性应激模型已被证明对抗抑郁药物的慢性治疗有反应。关于这种效应的两个问题仍未解决，即药物慢性给药的必要性以及不同药物剂量的治疗效果。本实验在析因设计中研究了这两个问题，其中在两个治疗期（急性（1小时）和慢性（3周））内改变了赋形剂和两种剂量的三环类抗抑郁药丙咪嗪。发现这两个因素均与治疗效果有显著相互作用，表明慢性治疗对于恢复是必要的，并且这种效果取决于药物水平。
