Arvidson N G, Terenius L
Acta Endocrinol (Copenh). 1982 Jun;100(2):290-4. doi: 10.1530/acta.0.1000290.
The structure-activity relationships of various natural and synthetic oestrogens, anti-oestrogens and some other steroid hormones with respect to early uterine albumin accumulation (EAV) was studied in sprayed mice. The results were compared with the activity of these agents to produce a late anabolic response (LAR). The potency ranking order among the oestrogens with respect to EAV was found to be oestradiol-17 beta, greater than oestriol, greater than meso-hexoestrol, greater than erythro-deoxyhexoestrol, greater than ent-oestradiol-17 beta, greater than (-)methallenestril phenol. Generally the oestrogens were much more potent with respect to EAV than LAR. No correlation was found when the ability to promote EAV and LAR was compared. Among other agents tested for effect on the EAV, progesterone, the synthetic progestogen, DU-41165 and the anti-hormones MER-25 and U-11100A (nafoxidine) showed no effect. However, hydrocortisone diminished EAV, while dihydrotestosterone increased EAV substantially.
在喷雾处理的小鼠中研究了各种天然和合成雌激素、抗雌激素及其他一些甾体激素与早期子宫白蛋白蓄积（EAV）之间的构效关系。将结果与这些药物产生晚期合成代谢反应（LAR）的活性进行了比较。发现雌激素中关于EAV的效价排序为：雌二醇-17β＞雌三醇＞内消旋己烯雌酚＞赤式脱氧己烯雌酚＞对映体雌二醇-17β＞（-）美雄烷雌酚酚。一般来说，雌激素对EAV的效力比对LAR的效力要强得多。比较促进EAV和LAR的能力时未发现相关性。在测试的对EAV有影响的其他药物中，孕酮、合成孕激素DU-41165以及抗激素MER-25和U-（11100A）（萘福昔定）均无作用。然而，氢化可的松可减少EAV，而双氢睾酮则可显著增加EAV。
