Bruce B K, King B M, Phelps G R, Veitia M C
Am J Physiol. 1982 Aug;243(2):E152-7. doi: 10.1152/ajpendo.1982.243.2.E152.
The present experiment was designed to assess the role of adrenal hormones in hypothalamic hyperphagia and obesity. Ventromedial hypothalamic (VMH) or sham lesions were produced either 15 days before or after adrenalectomy (ADX) or sham adrenalectomy in rats in a completely counterbalanced design (experiment 1). Body weight and food intake were recorded for 30 days after the second surgery. Adrenalectomy in obese VMH animals eliminated all excess weight gain and decreased food intake to below the level of all control groups. VMH lesions in ADX animals did not produce the characteristic weight gain associated with ventromedial hypothalamic damage, and this group was not significantly different from animals with sham lesions in body weight or food intake. In experiment 2, the administration of corticosterone resulted in a marked increase in the rate of weight gain in ADX-VMH animals, and the withdrawal of the hormones was followed by weight loss. It is concluded that adrenal glucocorticoid hormones are necessary for the development and maintenance of VMH hyperphagia and obesity.
本实验旨在评估肾上腺激素在下丘脑性食欲亢进和肥胖中的作用。采用完全平衡设计，在大鼠肾上腺切除术（ADX）或假肾上腺切除术之前或之后15天，制作腹内侧下丘脑（VMH）损伤或假损伤（实验1）。在第二次手术后记录30天的体重和食物摄入量。肥胖的VMH损伤动物进行肾上腺切除术后，消除了所有多余的体重增加，并使食物摄入量降至所有对照组以下。ADX动物的VMH损伤未产生与腹内侧下丘脑损伤相关的特征性体重增加，该组在体重或食物摄入量方面与假损伤动物无显著差异。在实验2中，给予皮质酮导致ADX-VMH动物体重增加速率显著增加，停止给予激素后体重减轻。结论是肾上腺糖皮质激素对于VMH性食欲亢进和肥胖的发生和维持是必需的。
