Reiner R, Rossmann K, van Hooidonk C, Ceulen B I, Bock J
Arzneimittelforschung. 1982;32(6):630-3.
Ointments for the protection against poisoning of the skin by highly toxic organophosphates or organophosphate insecticides were prepared and examined for their protective effect both on guinea-pig skin in vitro and on guinea-pigs in vivo. The results of these investigations were as follows: 1. The prophylactic application of the ointments yields 20 fold reduction of the permeation rate of the toxic organophosphate compared with unprotected skin. 2. The ointments on a polyethyleneglycol basis show their best protective effect if they contain both a base and an active substance. 3. Maximum possible protection can be achieved by applying a thick layer of ointment which should be mechanically removed (by wiping with a damp cellulose tissue) from the contamination site within 30 min.
制备了用于防止皮肤被剧毒有机磷酸盐或有机磷酸酯杀虫剂中毒的软膏，并在体外对豚鼠皮肤和体内对豚鼠进行了保护作用测试。这些研究结果如下：1. 与未保护的皮肤相比，预防性涂抹软膏可使有毒有机磷酸盐的渗透速率降低20倍。2. 以聚乙二醇为基础的软膏，若同时含有基质和活性物质，则显示出最佳保护效果。3. 涂抹一层厚软膏可实现最大程度的保护，应在30分钟内用湿纤维素组织擦拭将其从污染部位机械去除。
