Kagan E Z, Sinitsyna N I, Danilova V I, Berezina E K, Berezhinskaia V V
Antibiotiki. 1984 Sep;29(9):645-8.
The pharmacokinetics and safety of the lincomycin ointment and gel were studied. It was shown that diffusion of lincomycin through the skin was satisfactory. Investigation of their general toxicity and organotropic properties revealed neither irritating effect nor changes in the internal organs associated with the toxic effect of the drugs. On the basis of the data on the stability of the lincomycin ointment and gel obtained on their storage the lincomycin ointment was recommended for industrial production.
对林可霉素软膏和凝胶的药代动力学及安全性进行了研究。结果表明，林可霉素经皮肤的扩散情况良好。对它们的一般毒性和器官亲和性进行研究后发现，这些药物既没有刺激作用，也没有导致与毒性作用相关的内脏器官变化。根据林可霉素软膏和凝胶在储存过程中获得的稳定性数据，推荐林可霉素软膏用于工业生产。
