人血浆纤连蛋白可促进血小板在涂有纤维状胶原蛋白的表面上的黏附和铺展。
Human plasma fibronectin promotes the adhesion and spreading of platelets on surfaces coated with fibrillar collagen.
作者信息
Koteliansky V E, Leytin V L, Sviridov D D, Repin V S, Smirnov V N
出版信息
FEBS Lett. 1981 Jan 12;123(1):59-62. doi: 10.1016/0014-5793(81)80019-1.
This letter reports that human plasma fibronectin stimulates the interaction of platelets with fibrillar collagen (cell adhesion) and also dramatically changes the shape of adherent platelets, promoting their spreading. The stimulating effect of fibronectin is due to its interaction with collagen fibrils since free fibronectin does not influence the adhesion or spreading of platelets. The results obtained suggest a new physiological function for plasma fibronectin in the control of platelets interaction with damaged vessel walls.
本信函报道，人血浆纤连蛋白可刺激血小板与纤维状胶原蛋白的相互作用（细胞黏附），还能显著改变黏附血小板的形状，促进其铺展。纤连蛋白的刺激作用归因于它与胶原纤维的相互作用，因为游离的纤连蛋白不会影响血小板的黏附或铺展。所得结果提示血浆纤连蛋白在控制血小板与受损血管壁相互作用方面具有新的生理功能。
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