Grinnell F, Phan T V
Thromb Res. 1985 Jul 15;39(2):165-71. doi: 10.1016/0049-3848(85)90104-5.
Fibronectin promoted platelet attachment and spreading on polystyrene surfaces but was not essential if the surfaces were coated with plasma. The dependence of platelet adhesion on plasma concentration was complex. The extent of attachment and spreading was increased on surfaces treated with up to 1.0% plasma and decreased at higher plasma concentrations. The results support the hypothesis that protein adsorption is not directly related to protein concentration when surfaces are exposed to complex protein mixtures.
纤连蛋白可促进血小板在聚苯乙烯表面的黏附与铺展，但如果表面涂有血浆则并非必需。血小板黏附对血浆浓度的依赖性很复杂。在高达1.0%的血浆处理过的表面上，黏附与铺展程度增加，而在更高血浆浓度时则降低。这些结果支持了这样的假说，即当表面暴露于复杂蛋白质混合物时，蛋白质吸附与蛋白质浓度并无直接关系。
