Benton D, Brain P F
Dev Psychobiol. 1981 Mar;14(2):101-7. doi: 10.1002/dev.420140203.
Female "TO" strain mice were individually or group-housed for different durations (7-196 days). Behavioral reactivity was assessed for 3 days in an open field and an emergence test. Plasma samples were later collected after 5 min exposure to ethyl ether vapor; these generated "stress" corticosterone values. "Basal" corticosterone titers were obtained from similar untested and unanesthetized categories of mice. "Ether-stress" values were obtained from a limited number of mice subjected to ether anesthesia but no behavioral testing. Neither the basal nor the stress adrenocortical activities of the 2 housing categories differed. Open-field ambulation increased with longer durations of isolation, whereas for grouped mice it remained approximately constant. Individually housed mice had significantly lower defecation scores and longer emergence times than group-housed mice. In sum, little support was provided for the view that isolation is stressful.
雌性“TO”品系小鼠被单独或成群饲养不同时长（7 - 196天）。在旷场试验和出洞试验中对行为反应性进行了3天的评估。随后，在暴露于乙醚蒸气5分钟后采集血浆样本；这些样本得出“应激”皮质酮值。“基础”皮质酮滴度取自类似未经过测试且未麻醉的小鼠类别。“乙醚应激”值取自少量接受乙醚麻醉但未进行行为测试的小鼠。两种饲养类别的基础和应激肾上腺皮质活动均无差异。旷场活动随着隔离时间延长而增加，而成群饲养的小鼠活动则大致保持恒定。单独饲养的小鼠排便评分显著低于成群饲养的小鼠，出洞时间也更长。总之，几乎没有证据支持隔离会产生应激这一观点。
