通过支气管内滴注苯并[a]芘在兔体内诱发肺癌和淀粉样变性。
Production of lung cancer an amyloidosis in rabbits by intrabronchial instillation of benzo[a]pyrene.
作者信息
Hirao F, Nishikawa H, Yoshimoto T, Sakatani M, Namba M, Ogura T, Yamamura Y
出版信息
Gan. 1980 Apr;71(2):197-205.
PMID:7202916
Abstract
Carcinogenic activity of benzo[a]pyrene alone was tested for the induction of lung cancer in rabbits. Rabbits received intrabronchial instillation of 5 or 40 mg of benzo[a]pyrene suspended in sterile saline every 10 to 14 days. Cancer incidences were approximately 42% of the rabbits that survived for more than 300 days. These cancers included squamous cell carcinoma, adenocarcinoma, undifferentiated cell carcinoma, fibrosarcoma, and mixed type. In the same experiment amyloidosis was seen in 16 rabbits.
摘要
单独测试了苯并[a]芘诱发家兔肺癌的致癌活性。家兔每隔10至14天经支气管内滴注悬浮于无菌盐水中的5毫克或40毫克苯并[a]芘。存活超过300天的家兔中癌症发生率约为42%。这些癌症包括鳞状细胞癌、腺癌、未分化细胞癌、纤维肉瘤和混合型。在同一实验中，16只家兔出现了淀粉样变性。
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