Merin R G
Environ Health Perspect. 1978 Oct;26:169-74. doi: 10.1289/ehp.7826169.
Drug effects on myocardial contractile function are obviously of considerable practical importance for the toxicologist. The basic mechanism of such actions must reside at some point in the metabolism of cardiac muscle. Interference in the liberation of energy from the fuels that the heart uses may be implicated. It is possible that drugs may interfere with the storage (conservation) of that energy as the high energy phosphates (ATP and CP). Finally, the utilization of that stored energy by the contractile proteins themselves may be altered. The latter process is highly dependent on intracellular calcium ion kinetics. Anesthetic drugs, which produce reversible depression of myocardial contractile function is a dose-dependent fashion, have been shown to interfere to some extent with all three processes. However, the most important mechanism probably involves utilization of energy and intracellular calcium ion movement. A basic knowledge of the biochemistry of cardiac muscle is necessary for the understanding of drug action and toxicity at the subcellular level.
药物对心肌收缩功能的影响对毒理学家而言显然具有相当大的实际重要性。此类作用的基本机制必定存在于心肌代谢的某个环节。可能涉及干扰心脏所利用燃料中能量的释放。药物有可能干扰该能量以高能磷酸盐（ATP和CP）形式的储存（保存）。最后，收缩蛋白自身对所储存能量的利用可能会发生改变。后一过程高度依赖细胞内钙离子动力学。麻醉药物以剂量依赖方式产生心肌收缩功能的可逆性抑制，已表明在一定程度上会干扰所有这三个过程。然而，最重要的机制可能涉及能量利用和细胞内钙离子移动。要理解药物在亚细胞水平的作用和毒性，具备心肌生物化学的基本知识是必要的。
