Stromeyer F W, Ishak K G
Hum Pathol. 1981 Jan;12(1):60-71. doi: 10.1016/s0046-8177(81)80242-0.
Nodular transformation, a rare hyperplastic condition of the liver, has been reported in patients with rheumatoid arthritis, Felty's syndrome, the CRST syndrome, and myeloproliferative disorders. Associated disorders in the present clinicopathologic study of 30 cases included the foregoing as well as extrahepatic neoplasms, endocrine disorders, and other diseases producing immune dysfunction; some patients had received drug therapy for a prolonged time. Clinically nodular transformation may be confused with cirrhosis; histologic evaluation of liver biopsy material is essential for diagnosis. Complications include portal hypertension, hepatic failure, and rupture of the liver. Histologic and experimental evidence suggests that nodular transformation is preneoplastic, possibly giving rise to hepatocellular adenomas or carcinomas. Experimental and clinical data suggest that drugs should be considered as possible etiologic factors in the development of the nodules.
结节样转化是一种罕见的肝脏增生性疾病，在类风湿关节炎、费尔蒂综合征、CRST综合征和骨髓增殖性疾病患者中已有报道。在本次对30例病例的临床病理研究中，相关疾病包括上述疾病以及肝外肿瘤、内分泌紊乱和其他导致免疫功能障碍的疾病；一些患者长期接受药物治疗。临床上，结节样转化可能与肝硬化混淆；肝活检材料的组织学评估对诊断至关重要。并发症包括门静脉高压、肝衰竭和肝脏破裂。组织学和实验证据表明，结节样转化是肿瘤前病变，可能会发展为肝细胞腺瘤或癌。实验和临床数据表明，药物应被视为结节形成的可能病因。
