α2HS糖蛋白对人单核细胞吞噬功能的增强作用。
Enhancement of human monocyte phagocytic function by alpha 2HS glycoprotein.
作者信息
Lewis J G, André C M
出版信息
Immunology. 1981 Mar;42(3):481-7.
Abstract
Human alpha 2HS glycoprotein was isolated from normal adult serum and its effect on monocyte phagocytic function (in vitro) was investigated. The results demonstrate that alpha 2HS glycoprotein enhances the ability of peripheral blood monocytes to take up radiolabelled latex particles compared to control cells. Enhanced uptake required the simultaneous presence of cells, substrate and alpha 2HS glycoprotein. This uptake was dependent on the concentration of alpha 2HS glycoprotein offering the possibility that reduced levels of this protein, as in malignant and inflammatory disease, may result in decreased phagocytic function.
摘要
从正常成人血清中分离出人α2HS糖蛋白，并研究其对单核细胞吞噬功能（体外）的影响。结果表明，与对照细胞相比，α2HS糖蛋白增强了外周血单核细胞摄取放射性标记乳胶颗粒的能力。增强的摄取需要细胞、底物和α2HS糖蛋白同时存在。这种摄取依赖于α2HS糖蛋白的浓度，这表明在恶性和炎症性疾病中该蛋白水平降低可能导致吞噬功能下降。
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