Trnovec T, Gregusková M, Bezek S, Koprda V
Eur J Nucl Med. 1978;3(4):263-6. doi: 10.1007/BF00251403.
The organ distribution of 131I-o-iodohippurate (OIH) was studied in rats in the time interval of 1--1440 min. The mean decrease of OIH in plasma was fitted with a function composed of three exponential terms. A three-compartment model describing kinetics of OIH in rats was suggested and its parameters were computed. Comparison of organ and plasma concentrations of OIH showed that the liver, up to 30 min, and the heart and lungs, up to 15 min after administration, form with plasma a common central compartment.
在1至1440分钟的时间间隔内，研究了131I - 邻碘马尿酸（OIH）在大鼠体内的器官分布。血浆中OIH的平均减少量用由三个指数项组成的函数拟合。提出了一个描述OIH在大鼠体内动力学的三室模型，并计算了其参数。OIH器官浓度与血浆浓度的比较表明，给药后30分钟内的肝脏以及给药后15分钟内的心脏和肺与血浆形成一个共同的中央室。
