Ringhand H P, Ritschel W A, Meyer M C, Straughn A B, Hardt T
Int J Clin Pharmacol Ther Toxicol. 1980 Nov;18(11):488-93.
A pharmacokinetic analysis of propylthiouracil (PTU) plasma concentration versus time data for twelve euthyroid subjects was performed using the NONLIN computer program. The plasma concentration-time curves were best described by a one-compartment open model. PTU was administered to fasted subjects as a single 150-mg peroral dose. Venous blood samples were taken for a period of 8 hrs, and the concentration of unmetabolized PTU was determined by a new specific high-pressure liquid chromatographic procedure. Estimates of pharmacokinetic parameters generated in the study were compared with corresponding parameters reported in the literature.
使用NONLIN计算机程序对12名甲状腺功能正常的受试者的丙硫氧嘧啶（PTU）血浆浓度与时间数据进行了药代动力学分析。血浆浓度-时间曲线用单室开放模型能得到最佳描述。PTU以单次口服150毫克的剂量给予空腹受试者。采集静脉血样8小时，并通过一种新的特定高压液相色谱法测定未代谢PTU的浓度。将该研究中产生的药代动力学参数估计值与文献中报道的相应参数进行比较。
