O'Grady J, Oh V, Turner P
Eur J Clin Pharmacol. 1978 Nov 16;14(2):83-5. doi: 10.1007/BF00607435.
The effects of oxprenolol and propranolol on the venoconstrictor response to noradrenaline were studied in healthy volunteers by measuring superficial dorsal hand vein diameter at a standard congesting pressure. In 8 subjects dose response curves to noradrenaline (20-1280 ng/ml) were obtained with noradrenaline alone, with noradrenaline plus propranolol 10 microgram/ml, with noradrenaline plus propranolol 10 microgram/ml plus oxprenolol 3 microgram/ml and with noradrenaline plus propranolol 13 microgram/ml according to a double blind balanced randomised design. Propranolol 10 microgram/ml significantly (p less than 0.05) potentiated the vasoconstrictor response to noradrenaline and the addition of oxprenolol significantly (P less than 0.05) reversed the potentiation giving a response similar to that seen with noradrenaline alone. The higher concentration of propranolol did not produce further potentiation, the response being similar to that obtained with the lower concentration of propranolol. It is suggested that the effect of oxprenolol may be attributable to alpha blocking properties, to partial beta agonism or to its membrane stabilising properties.
通过在标准充血压力下测量手背浅静脉直径，研究了氧烯洛尔和普萘洛尔对去甲肾上腺素引起的静脉收缩反应的影响。在8名受试者中，根据双盲平衡随机设计，分别单独使用去甲肾上腺素（20 - 1280 ng/ml）、去甲肾上腺素加10微克/毫升普萘洛尔、去甲肾上腺素加10微克/毫升普萘洛尔加3微克/毫升氧烯洛尔以及去甲肾上腺素加13微克/毫升普萘洛尔，获得了对去甲肾上腺素的剂量反应曲线。10微克/毫升普萘洛尔显著（p < 0.05）增强了对去甲肾上腺素的血管收缩反应，而加入氧烯洛尔则显著（P < 0.05）逆转了这种增强作用，使其反应类似于单独使用去甲肾上腺素时的反应。较高浓度的普萘洛尔并未产生进一步的增强作用，其反应与较低浓度普萘洛尔时获得的反应相似。提示氧烯洛尔的作用可能归因于α阻断特性、部分β激动作用或其膜稳定特性。
