Ono K, Baba H, Mori K
Int J Neurosci. 1981;12(2):79-85. doi: 10.3109/00207458108985792.
Simultaneously recorded multielectrode EEG data obtained during the course of amygdaloid kindling in cats were quantitatively analyzed by means of a multidimensional autoregressive model. By the use of this method, the afterdischarge was objectively separated into propagated and reactive discharge respectively in the frequency domain and it permitted the study of the progressive development of reactive afterdischarge which has been suggested to have a functional relationship with seizure development. As a result, marked augmentation and a tendency for synchronization of reactive afterdischarge were noted in the midbrain reticular formation and anteroventral part of the thalamus along with seizure development. Furthermore, a remarkable contribution to producing afterdischarges at other brain sites was revealed. Such contribution of the reticular system as a pacemaker was also shown by analysis of the background EEG. From the above findings obtained in kindling preparation of cats through multidimensional autoregressive analysis, a new approach to the mechanism of kindling phenomenon was demonstrated and a possible mechanism was also discussed.
利用多维自回归模型对猫杏仁核点燃过程中同步记录的多电极脑电图数据进行了定量分析。通过这种方法，在频域中客观地将后放电分别分为传播性放电和反应性放电，并能够研究反应性后放电的渐进发展，而反应性后放电被认为与癫痫发作的发展存在功能关系。结果发现，随着癫痫发作的发展，中脑网状结构和丘脑腹前部的反应性后放电明显增强且有同步化趋势。此外，还揭示了其对其他脑区产生后放电的显著贡献。对背景脑电图的分析也显示了网状系统作为起搏器的这种作用。通过对猫点燃模型的多维自回归分析得到的上述发现，展示了一种研究点燃现象机制的新方法，并对可能的机制进行了讨论。
