Yokoyama M M, Matsui Y, Yamashiroya H M, O'Donnell M J, Tseng C H, Snyder D A, Tessler H H, Crispen R G, Zimjewski C M
Invest Ophthalmol Vis Sci. 1981 Mar;20(3):364-70.
We performed a comprehensive immunologic assessment of 17 patients with Vogt-Koyanagi-Harada syndrome (VKH) and nine with pars planitis (PP). Several variations in humoral and cellular immunity were found when the patients were compared with normal controls. Elevated serum IgD levels, positive results from various autoimmune profile assays, and deviations from normal levels of viral antibody titers were noted in both groups of patients. However, only some VKH patients had elevated beta 2 microglobulin, total complement level and E-active and EA rosette counts. HLA haplotype typing revealed no distinct correlation between patients when compared with a normal population.
我们对17例Vogt-小柳原田综合征（VKH）患者和9例中间葡萄膜炎（PP）患者进行了全面的免疫评估。将这些患者与正常对照组进行比较时，发现体液免疫和细胞免疫存在多种差异。两组患者均出现血清IgD水平升高、各种自身免疫谱检测结果呈阳性以及病毒抗体滴度偏离正常水平的情况。然而，只有部分VKH患者的β2微球蛋白、总补体水平以及E活性和EA花环计数升高。与正常人群相比，HLA单倍型分型显示患者之间无明显相关性。
