Goh K O
Invest Radiol. 1980 Jul-Aug;15(4):332-4. doi: 10.1097/00004424-198007000-00010.
Chromosomal breaks are seen in the peripheral blood lymphocytes of irradiated patients long after the original exposure. This is confirmed in our present investigation. We found 141 (20%) chromosomal breaks in 707 metaphases from 18 thymus-irradiated patients and only 26 (6.3%) in 410 metaphases from six of their normal siblings. Sister chromatid exchange (SCE) has been used to test the mutagen-carcinogen agents. However, radiation, a well-known mutagen-carcinogen agent, has no effect upon SCE. This suggests that the SCE and chromosomal breakage mechanisms may be quite different; study of them may help us to understand chromosomal breakage and healing.
在最初接受辐射后的很长时间里，在受辐射患者的外周血淋巴细胞中可观察到染色体断裂。这在我们目前的研究中得到了证实。我们在18名接受胸腺照射患者的707个中期相中发现了141个（20%）染色体断裂，而在他们6名正常兄弟姐妹的410个中期相中仅发现了26个（6.3%）。姐妹染色单体交换（SCE）已被用于检测诱变致癌剂。然而，辐射作为一种众所周知的诱变致癌剂，对SCE没有影响。这表明SCE和染色体断裂机制可能大不相同；对它们的研究可能有助于我们理解染色体的断裂和修复。
